Niemann-Pick disease Type C – causes, symptoms, diagnosis, treatment, pathology

Niemann-Pick disease Type C – causes, symptoms, diagnosis, treatment, pathology

Niemann-Pick disease type C, or NPC, is a rare genetically inherited condition caused by mutations in either the NPC1 or NPC2 genes. These mutations impair intracellular transport of cholesterol and other molecules, which causes progressive neurologic and developmental problems. Now, cholesterol reaches the cells packed in lipoproteins, which bind to low density lipoprotein, or LDL,

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Posttransplant lymphoproliferative disorders – causes, symptoms, diagnosis, treatment, pathology

Posttransplant lymphoproliferative disorders – causes, symptoms, diagnosis, treatment, pathology

Posttransplant lymphoproliferative disorders, or PTLDs, are uncontrolled growths of cells called lymphocytes that may occur in transplant recipients after receiving a solid organ, such as a kidney or a lung, or stem cells. Transplant recipients require medications to suppress their immune systems which may contribute to the development of a PTLD. Normally, immune cells can

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