Metachromatic leukodystrophy – causes, symptoms, diagnosis, treatment, pathology

Metachromatic leukodystrophy – causes, symptoms, diagnosis, treatment, pathology

Metachromatic leukodystrophy, or MLD, is a rare lysosomal storage disorder that results from mutations in the ARSA gene, which codes for arylsulfatase A – an enzyme that normally breaks down a fat called sulfatide. Without this enzyme, sulfatide accumulates in neurons and myelin-producing cells like Schwann cells and oligodendrocytes, resulting in their degeneration. MLD is

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Canola diseases in 2015 with Steve Marcroft

Canola diseases in 2015 with Steve Marcroft

This year we’ve got a bit of a focus on fungicide tolerance. Blackleg is a sexually reproducing disease, so it’s got enormous genetic diversity and we’ve seen in the past that it overcomes the cultivar resistance in our cultivars and we’ve always been suspicious that it might also overcome fungicides that we use. So last

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Niemann-Pick disease Type C – causes, symptoms, diagnosis, treatment, pathology

Niemann-Pick disease Type C – causes, symptoms, diagnosis, treatment, pathology

Niemann-Pick disease type C, or NPC, is a rare genetically inherited condition caused by mutations in either the NPC1 or NPC2 genes. These mutations impair intracellular transport of cholesterol and other molecules, which causes progressive neurologic and developmental problems. Now, cholesterol reaches the cells packed in lipoproteins, which bind to low density lipoprotein, or LDL,

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